Access from Dallas, TX: Take I-30 north to Little Rock, AR, then I-40 to Conway where you exit north on U.S. 65 to Marshall. At Marshall, take AR 27 east to Harriet where you connect with AR 14. Continue traveling north, crossing the Buffalo National River, until you reach Yellville. Then, travel east on U.S. 62/412 through Flippin, Cotter and Gassville to Mountain Home.
Access from Memphis, TN: Take I-40 west to West Memphis, AR, then I-55 north 16 miles to U.S. 63. Take U.S. 63 north to Hardy, AR, then take U.S. 62/412 west to Mountain Home.
Access from Tulsa, OK: Take U.S. 412 east to Siloam Springs, AR, and follow U.S. 412 to Alpena, AR. At Alpena, take U.S. 62/412 east to Mountain Home.
Access from Kansas City, MO: Take U.S. 71 south to Harrisonville, then MO 7 to Clinton. From Clinton, take MO 13 to Springfield. Take I-44 east to U.S. 65, then south to U.S. 60. Take U.S. 60 east to Mansfield, MO, then MO 5 south to the state line, where the highway becomes AR 5. Take AR 5 south to Mountain Home.
Access from St. Louis, MO: Take I-44 south to Lebanon, MO. Then take MO 5 south through Ava, Mansfield and Gainesville to the state line, where the highway becomes AR 5. Take AR 5 south to Mountain Home.